Yagil Y, Kobrin I, Stessman J, Ghanem J, Leibel B, Ben-Ishay D
Hypertension. 1983 Jul-Aug;5(4 Pt 2):II113-7. doi: 10.1161/01.hyp.5.4_pt_2.ii113.
The long-term antihypertensive effect of combined nifedipine and propranolol therapy was assessed in an open trial in 26 hypertensive patients (19 men, seven women, mean age 53 years). On propranolol alone (160 to 240 mg/day), the patients' average sitting blood pressure was 192 +/- 5/114 +/- 2 mm Hg. Propranolol was continued in a fixed dose and nifedipine was added in a dose that was gradually increased from 30 to 90 mg/day to achieve blood pressure (BP) values below 160/95 mm Hg. Twenty-two patients remained on the combined regimen for 14 to 30 weeks. Their BP decreased to 136 +/- 3/84 +/- 2 mm Hg on an average daily dose of 59.5 mg nifedipine. Seventeen of the 22 subjects were subsequently treated sequentially with propranolol alone, combined therapy, and nifedipine alone, to assess the relative efficacy of each mode of therapy. The combined regimen was found to be more effective than either drug alone. Side effects occurred in 13 of 26 patients. Four dropped out 4 to 11 weeks after starting nifedipine because of either intolerable flushing (2), allergic rash (1), or headache (1). Nine subjects experienced mild reactions that were well tolerated. It is concluded that the combined use of propranolol and nifedipine is effective in the long-term treatment of moderately severe hypertension and offers an alternative therapeutic approach that deserves further evaluation.
在一项开放性试验中，对26例高血压患者（19例男性，7例女性，平均年龄53岁）评估了硝苯地平与普萘洛尔联合治疗的长期降压效果。仅使用普萘洛尔（每日160至240毫克）时，患者的平均坐位血压为192±5/114±2毫米汞柱。普萘洛尔维持固定剂量，并添加硝苯地平，剂量从每日30毫克逐渐增加至90毫克，以使血压（BP）值低于160/95毫米汞柱。22例患者持续联合治疗方案14至30周。他们在平均每日服用59.5毫克硝苯地平的情况下，血压降至136±3/84±2毫米汞柱。随后，22名受试者中的17名依次接受了单独使用普萘洛尔、联合治疗和单独使用硝苯地平的治疗，以评估每种治疗方式的相对疗效。结果发现联合治疗方案比单独使用任何一种药物都更有效。26例患者中有13例出现副作用。4例在开始使用硝苯地平4至11周后因无法耐受的面部潮红（2例）、过敏性皮疹（1例）或头痛（1例）而退出。9名受试者出现了耐受性良好的轻度反应。结论是，普萘洛尔和硝苯地平联合使用对中度重度高血压的长期治疗有效，并提供了一种值得进一步评估的替代治疗方法。
