Voelz G L, Wilkinson G S, Acquavella J F, Tietjen G L, Brackbill R N, Reyes M, Wiggs L D
Health Phys. 1983;44 Suppl 1:493-503. doi: 10.1097/00004032-198306001-00048.
Retrospective and prospective epidemiologic studies are being conducted as part of a national survey of plutonium workers at four Department of Energy facilities (Los Alamos, NM; Rocky Flats, CO; Mound Laboratory, OH; and Savannah River, SC). A preliminary analysis of mortality was done for all white males who have worked at the Rocky Flats Plant during the period 1952-79. The 452 observed deaths were significantly fewer than the 831 expected for all causes. The 107 deaths due to all malignant neoplasms were also significantly fewer than the 167 expected from these diseases. Expected deaths were derived from age and calendar-specific death rates for U.S. white males. Deaths reported for benign and unspecified neoplasms numbered eight versus an expected two, a significant elevation. These tumors, all intracranial, are the subject of a case-control study to be reported later. Subdividing the cohort on the basis of plutonium exposures and external radiation exposures results in similar overall findings. The benign and unspecified neoplasms, however, were not significantly high in the plutonium-exposed group.
作为对能源部四个设施（新墨西哥州洛斯阿拉莫斯；科罗拉多州洛基弗拉茨；俄亥俄州芒德实验室；南卡罗来纳州萨凡纳河）钚作业工人进行的全国性调查的一部分，正在开展回顾性和前瞻性流行病学研究。对1952年至1979年期间在洛基弗拉茨工厂工作的所有白人男性的死亡率进行了初步分析。观察到的452例死亡人数明显少于所有原因预期的831例。所有恶性肿瘤导致的107例死亡人数也明显少于这些疾病预期的167例。预期死亡人数是根据美国白人男性的年龄和日历特定死亡率得出的。良性和未明确肿瘤报告的死亡人数为8例，而预期为2例，有显著升高。这些肿瘤均为颅内肿瘤，是一项病例对照研究的对象，该研究结果将在稍后报告。根据钚暴露和外部辐射暴露对队列进行细分，总体结果相似。然而，在钚暴露组中，良性和未明确肿瘤的发生率并没有显著升高。
