Wiggs L D, Johnson E R, Cox-DeVore C A, Voelz G L
Los Alamos National Laboratory, NM 87545.
Health Phys. 1994 Dec;67(6):577-88. doi: 10.1097/00004032-199412000-00001.
A cohort mortality study was conducted of 15,727 white men employed by the Los Alamos National Laboratory, a nuclear research and development facility. Some of the workers at this facility have been exposed to various forms of ionizing radiation and other potentially hazardous materials. These analyses focused on whole-body ionizing radiation exposures and internal depositions of plutonium. The results indicated that overall mortality among this cohort is quite low, even after nearly 30 y of follow-up. No cause of death was significantly elevated among plutonium-exposed workers when compared with their unexposed coworkers; however, a rate ratio for lung cancer of 1.78 (95% CI = 0.79-3.99) was observed. A case of osteogenic sarcoma, a type of cancer related to plutonium exposure in animal studies, was also observed. Dose-response relationships for whole-body dose from external ionizing radiation and tritium were observed for cancers of the brain/central nervous system, the esophagus, and Hodgkin's disease.
对洛斯阿拉莫斯国家实验室（一个核研究与开发机构）雇佣的15727名白人男性进行了队列死亡率研究。该机构的一些工作人员曾接触过各种形式的电离辐射和其他潜在有害物质。这些分析聚焦于全身电离辐射暴露和钚的体内沉积。结果表明，即使经过近30年的随访，该队列的总体死亡率相当低。与未接触钚的同事相比，接触钚的工人中没有任何死因显著升高；然而，观察到肺癌的率比为1.78（95%置信区间=0.79 - 3.99）。还观察到一例骨肉瘤，这是一种在动物研究中与钚暴露相关的癌症类型。观察到外部电离辐射和氚产生的全身剂量与脑/中枢神经系统癌、食道癌和霍奇金病之间的剂量反应关系。
