Mewhinney J A, Griffith W C
Health Phys. 1983;44 Suppl 1:537-44. doi: 10.1097/00004032-198306001-00052.
A model useful for predicting lung retention and tissue distribution following human inhalation exposure to 241AmO2 has been formulated. The model is based on inhalation studies in beagles exposed to either monodisperse or polydisperse aerosols of 241AmO2. It also describes lung retention for several cases of accidental human inhalation exposure to 241Am adequately. The model incorporates an expression for solubilization of 241AmO2 deposited in lung which is based on physicochemical characteristics of the inhaled particles. Comparison of predictions from this model and those of the International Commission of Radiological Protection in ICRP Publication 30 shows some important differences. Lung retention patterns of inhaled 241Am in dogs and humans after inhalation of 241AmO2 are very similar and do not conform with predictions of the ICRP 30 model. Although use of the ICRP 30 model for calculation of annual limits of intake produces similar values to predictions made from our model, a more complete assessment of accidental human exposures to 241AmO2 and the risk to individual organs can be made using the retention and dosimetry model formulated from these studies in dogs.
已经建立了一个模型，可用于预测人类吸入241AmO2后的肺部滞留和组织分布情况。该模型基于对暴露于单分散或多分散241AmO2气溶胶的比格犬进行的吸入研究。它也能够充分描述几例人类意外吸入241Am后的肺部滞留情况。该模型纳入了一个基于吸入颗粒物理化学特性的241AmO2在肺部沉积后溶解的表达式。将该模型的预测结果与国际放射防护委员会（ICRP）第30号出版物中的预测结果进行比较，发现了一些重要差异。吸入241AmO2后，狗和人类吸入的241Am的肺部滞留模式非常相似，与ICRP 30模型的预测结果不符。虽然使用ICRP 30模型计算年摄入量限值得出的值与我们模型的预测值相似，但使用从这些对狗的研究中建立的滞留和剂量测定模型，可以对人类意外暴露于241AmO2的情况以及对各个器官的风险进行更全面的评估。
