Mewhinney J A, Griffith W C
Health Phys. 1982 May;42(5):629-44. doi: 10.1097/00004032-198205000-00006.
Two models of the metabolism of inhaled 241AmO2 in Beagles have been formulated. these models differ in their description of lung retention; the empirical dissolution model uses an empirically derived function to describe dissolution of inhaled 241AmO2 while the surface area model uses a dissolution function based on physical and chemical characteristics of the inhaled aerosol. Both models provide more accurate descriptions of retention data for 241Am from several studies in Beagles than does the model published by the ICRP. The surface area model is extended to describe several cases of inhalation of 241Am in humans. This latter model is employed to calculate Annual Limits of Intake for comparison with results based on the current ICRP model.
已建立了两种比格犬吸入241AmO2代谢模型。这些模型在肺部滞留的描述上有所不同；经验溶解模型使用经验推导函数来描述吸入的241AmO2的溶解，而表面积模型则使用基于吸入气溶胶物理和化学特性的溶解函数。与ICRP发布的模型相比，这两种模型都能更准确地描述比格犬多项研究中241Am的滞留数据。表面积模型被扩展以描述人类吸入241Am的几种情况。后一种模型用于计算摄入量的年限值，以便与基于当前ICRP模型的结果进行比较。
