Mewhinney J A, Griffith W C, Muggenburg B A
Health Phys. 1982 May;42(5):611-27. doi: 10.1097/00004032-198205000-00005.
Beagle dogs received a single inhalation exposure to a monodisperse or a polydisperse aerosol of 241AmO2 to determine the radiation dose to internal organs. Three monodisperse aerosol sizes (0.75, 1.5 and 3.0 micrometer activity median aerodynamic diameter) and one polydisperse aerosol (1.8 micrometer activity median aerodynamic diameter) were used to assess the role of particle size in clearance of 241AmO2 from the lung and the rate of translocation of 241Am to other tissues. Dogs were sacrificed in groups of two or three at 8, 32, 64, 128, 256, 365 and 730 days after exposure. The clearance rate of 241Am from lung was particle size dependent; this resulted in an increased radiation dose to lung at 2 yr by 70% as particle size increased from 0.75 to 3.0 micrometer aerodynamic diameter. Conversely, the radiation dose to liver and skeleton decreased by 20 and 35% respectively as particle size increased from 0.75 to 3.0 micrometer activity median aerodynamic diameter. When the radiation doses absorbed by lung, liver and skeleton were compared to those predicted by the ICRP 30 model, differences were noted.
比格犬单次吸入241AmO2的单分散或多分散气溶胶，以确定其内部器官的辐射剂量。使用三种单分散气溶胶尺寸（活性中值空气动力学直径分别为0.75、1.5和3.0微米）和一种多分散气溶胶（活性中值空气动力学直径为1.8微米）来评估粒径在241AmO2从肺清除过程中的作用以及241Am向其他组织的转运速率。在暴露后的第8、32、64、128、256、365和730天，将犬按每组两到三只进行处死。241Am从肺的清除率取决于粒径；随着粒径从0.75微米空气动力学直径增加到3.0微米，导致2年后肺所接受的辐射剂量增加了70%。相反，随着粒径从0.75微米活性中值空气动力学直径增加到3.0微米，肝脏和骨骼所接受的辐射剂量分别降低了20%和35%。当将肺、肝脏和骨骼所吸收的辐射剂量与ICRP 30模型预测的剂量进行比较时，发现了差异。
