Harwood A R
Int J Radiat Oncol Biol Phys. 1983 Jul;9(7):1019-21. doi: 10.1016/0360-3016(83)90391-7.
Lentigo maligna (LM) and lentigo maligna melanoma (LMM) are distinct entities from other forms of melanoma, occurring predominantly on the skin of the head and neck in elderly people, having a slow growth rate and a low metastatic potential (10%). Twenty-three patients with LM were treated with conventional fractionated irradiation, 18 were locally controlled and two failed locally both of whom, however, were salvaged with further treatment. Three patients are not evaluable because of short follow-up time. Median time to complete regression of the lesion is seven months. Twenty-eight patients with LMM have been irradiated, 23 are locally controlled, two locally recurred (both retrieved with subsequent treatment), and three are inevaluable because of short follow-up time. One patient with a level 5 LMM has developed regional and distant metastases. It is concluded that irradiation is a simple effective method of treatment for this form of melanoma.
恶性雀斑样痣（LM）和恶性雀斑样痣黑色素瘤（LMM）与其他类型的黑色素瘤不同，主要发生于老年人的头颈部皮肤，生长缓慢且转移潜能低（10%）。23例LM患者接受了常规分割放疗，18例局部得到控制，2例局部治疗失败，但二者均经进一步治疗后好转。3例因随访时间短而无法评估。病灶完全消退的中位时间为7个月。28例LMM患者接受了放疗，23例局部得到控制，2例局部复发（二者均经后续治疗后好转），3例因随访时间短而无法评估。1例5级LMM患者发生了区域和远处转移。结论是，放疗是治疗这种类型黑色素瘤的一种简单有效的方法。
