Dancuart F, Harwood A R, Fitzpatrick P J
Cancer. 1980 May 1;45(9):2279-83. doi: 10.1002/1097-0142(19800501)45:9<2279::aid-cncr2820450910>3.0.co;2-h.
Between 1958 and 1977, 8 cases of lentigo maligna (LM) and 15 cases of lentigo maligna melanoma (LMM) were treated with radiotherapy at the Princess Margaret Hospital. Only 1 of the 8 cases of LM recurred following irradiation and this recurrence was controlled with further radiotherapy. Of 15 cases of LMM, 14 were controlled by irradiation for periods ranging from two months to six years postradiotherapy; the 1 recurrence was salvaged with local excision. Conventional orthovoltage irradiation using doses of 4500--5000 rad in ten to 15 fractions has been found to be highly effective in controlling this disease. The lesion may take up to 24 months to completely regress following irradiation. The benefits of this modality of treatment for a disease process which predominantly occurs in the head and neck region of elderly people is discussed in detail. The results are compared with other methods of irradiation (Miescher's technique) and other modalities of treatment.
1958年至1977年间，玛格丽特公主医院对8例恶性雀斑样痣（LM）和15例恶性雀斑样痣黑色素瘤（LMM）进行了放射治疗。8例LM患者中只有1例在放疗后复发，再次放疗控制了复发。15例LMM患者中，14例在放疗后2个月至6年期间通过放疗得到控制；1例复发通过局部切除挽救。已发现使用4500 - 5000拉德剂量分十至十五次的传统深部X线放疗在控制这种疾病方面非常有效。放疗后病变可能需要长达24个月才能完全消退。详细讨论了这种治疗方式对主要发生在老年人头颈部的疾病过程的益处。将结果与其他放疗方法（米舍尔技术）和其他治疗方式进行了比较。
