Harwood A R
J Am Acad Dermatol. 1982 Mar;6(3):310-6. doi: 10.1016/s0190-9622(82)70021-0.
Forty cases of lentigo maligna (LM) and lentigo maligna melanoma (LMM) treated by conventional fractionated radiotherapy are reviewed. Fourteen of seventeen LM patients are alive and well 4 months to 5 years following irradiation, one patient died of intercurrent disease without recurrence, and two had residual or recurrent tumor (both salvaged by excision or further irradiation). Twenty-one of twenty-three LMM patients had their tumor controlled from 1 month to 7 years following irradiation. Two recurred locally or had residual tumor, and both were salvaged by excision. There have been no regional or distant recurrences of melanoma in the entire series. Cosmetic results of treatment are excellent. The lesions can take up to 24 months to disappear following irradiation. It is concluded that conventional fractionated radiotherapy is simple, effective outpatient treatment worthy of further study for LM and LMM.
回顾了40例采用常规分割放疗治疗的恶性雀斑样痣（LM）和恶性雀斑样痣黑色素瘤（LMM）患者。17例LM患者中有14例在放疗后4个月至5年存活且状况良好，1例患者死于并发疾病，无复发，2例有残留或复发性肿瘤（均通过切除或进一步放疗挽救）。23例LMM患者中有21例在放疗后1个月至7年肿瘤得到控制。2例局部复发或有残留肿瘤，均通过切除挽救。整个系列中均未出现黑色素瘤的区域或远处复发。治疗的美容效果极佳。放疗后病变最多需要24个月才能消失。结论是，常规分割放疗是一种简单、有效的门诊治疗方法，值得对LM和LMM进行进一步研究。
