Hirsch V M, Doige C E
J Am Vet Med Assoc. 1983 Jun 1;182(11):1223-6.
Suppurative cholangitis in 5 aged cats was characterized clinically by weight loss, depression, dehydration, icterus, and fever. The major abnormal laboratory findings were a severe left shift of WBC and a high, conjugated bilirubin concentration consistent with an inflammatory process and cholestasis. Gross pathologic findings included periductal biliary fibrosis (4 cats), periductal pancreatic fibrosis (2 cats), cholelithiasis (2 cats), deformation of the gallbladder (2 cats), and chronic interstitial pancreatitis (2 cats). Histopathologic findings in all cases were portal hepatic fibrosis, biliary hyperplasia, and suppurative exudate within dilated intrahepatic biliary ducts. Weight loss and portal fibrosis were suggestive of chronic, intermittent illness. The pathogenesis appeared to involve invasion of the bile duct by enteric bacteria. Cholangitis was observed to occur in association with pancreatitis, cholelithiasis, or anatomic abnormalities of the biliary tract.
5只老龄猫的化脓性胆管炎临床特征为体重减轻、精神沉郁、脱水、黄疸和发热。主要的实验室异常结果为白细胞严重左移以及高结合胆红素浓度，这与炎症过程和胆汁淤积一致。大体病理结果包括胆管周围胆汁纤维化（4只猫）、胆管周围胰腺纤维化（2只猫）、胆结石（2只猫）、胆囊变形（2只猫）和慢性间质性胰腺炎（2只猫）。所有病例的组织病理学结果均为门静脉肝纤维化、胆管增生以及扩张的肝内胆管内有化脓性渗出物。体重减轻和门静脉纤维化提示为慢性间歇性疾病。发病机制似乎涉及肠道细菌侵入胆管。观察到胆管炎与胰腺炎、胆结石或胆道解剖异常有关。
