Prasse K W, Mahaffey E A, DeNovo R, Cornelius L
Vet Pathol. 1982 Mar;19(2):99-108. doi: 10.1177/030098588201900201.
Wedge biopsy of the liver during episodic clinical illness in three male cats showed lymphocytic cholangitis. Principal clinical findings were increased serum alkaline phosphatase activity and hepatomegaly (two cats) associated with anorexia, pyrexia. and weight loss; these signs of illness were intermittent with asymptomatic periods. The hepatic lesions were characterized by lymphoid aggregate or follicle formation, diffusely dispersed lymphocytes and plasma cells, and abnormal bile ducts and ductules. Lymphoid aggregates and diffusely scattered lymphocytes were seen in the pancreas also. The spectrum of hepatic lesions in three cats seemed to represent a progression in the development of the disease. Similarities and dissimilarities between the findings in the three cats and human primary biliary cirrhosis or chronic nonsuppurative destruction cholangitis are discussed. During a prospective search for cats with this disease, other hepatis lesions were found, and it was concluded that cats may be affected by more than one pathogenic mechanism culminating in chronic cholangitis or cholangiohepatitis.
对三只雄性猫在发作性临床疾病期间进行肝脏楔形活检，结果显示为淋巴细胞性胆管炎。主要临床发现为血清碱性磷酸酶活性升高和肝肿大（两只猫），伴有厌食、发热和体重减轻；这些疾病体征呈间歇性，其间有无症状期。肝脏病变的特征为淋巴样聚集或滤泡形成、弥漫性散在的淋巴细胞和浆细胞，以及异常的胆管和小胆管。在胰腺中也可见到淋巴样聚集和弥漫性散在的淋巴细胞。三只猫的肝脏病变谱似乎代表了该疾病发展过程中的一个进展阶段。文中讨论了三只猫的检查结果与人类原发性胆汁性肝硬化或慢性非化脓性破坏性胆管炎之间的异同。在对患有这种疾病的猫进行前瞻性搜索过程中，还发现了其他肝脏病变，得出的结论是，猫可能受到多种致病机制的影响，最终导致慢性胆管炎或胆管肝炎。
