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J Bacteriol. 1983 Jul;155(1):138-44. doi: 10.1128/jb.155.1.138-144.1983.
2
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Alanine ester-containing native lipoteichoic acids do not act as lipoteichoic acid carrier. Isolation, structural and functional characterization.含丙氨酸酯的天然脂磷壁酸不作为脂磷壁酸载体。分离、结构及功能表征。
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Teichoic acids from chemostat-grown cultures of Streptococcus mutans and Lactobacillus plantarum.来自变形链球菌和植物乳杆菌恒化器培养物的磷壁酸。
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蛋白质合成抑制过程中脂磷壁酸的碳水化合物取代增加。

Increased carbohydrate substitution of lipoteichoic acid during inhibition of protein synthesis.

作者信息

Kessler R E, Wicken A J, Shockman G D

出版信息

J Bacteriol. 1983 Jul;155(1):138-44. doi: 10.1128/jb.155.1.138-144.1983.

DOI:10.1128/jb.155.1.138-144.1983
PMID:6863217
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC217662/
Abstract

Decreases in electrophoretic mobilities of intracellular lipoteichoic acid, intracellular deacylated lipoteichoic acid, and extracellular deacylated lipoteichoic acid were observed during inhibition of protein synthesis in Streptococcus faecium after exposure to chloramphenicol or valine deprivation. Increased carbohydrate content, and thus an increased mass-to-charge ratio, rather than changes in ester alanine content or novel fatty acid substitutions, appeared to account for the decreased electrophoretic mobilities. The increase in carbohydrate content, as judged from mobility measurements, was progressive over time and appeared to occur on biosynthetically new lipoteichoic acid as well as on lipoteichoic acid made before inhibition of protein synthesis.

摘要

在粪肠球菌暴露于氯霉素或缬氨酸缺乏后抑制蛋白质合成的过程中，观察到细胞内脂磷壁酸、细胞内去酰基脂磷壁酸和细胞外去酰基脂磷壁酸的电泳迁移率降低。碳水化合物含量增加，从而质荷比增加，而非酯丙氨酸含量的变化或新的脂肪酸取代，似乎是电泳迁移率降低的原因。根据迁移率测量判断，碳水化合物含量的增加随时间逐渐发生，并且似乎发生在生物合成的新脂磷壁酸以及蛋白质合成抑制前产生的脂磷壁酸上。