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粪肠球菌ATCC 9790膜脂磷壁酸甘油磷酸聚合物的延伸模式。

Mode of elongation of the glycerol phosphate polymer of membrane lipoteichoic acid of Streptococcus faecium ATCC 9790.

作者信息

Cabacungan E, Pieringer R A

出版信息

J Bacteriol. 1981 Jul;147(1):75-9. doi: 10.1128/jb.147.1.75-79.1981.

Abstract

Specific degradation of membrane lipoteichoic acid of Streptococcus faecium ATCC 9790 by a phosphodiesterase from Aspergillus niger and by periodate oxidation has demonstrated that the enzymatic synthesis of the glycerol phosphate polymer of the molecule occurs by an external elongation system. Evidence of this type of mechanism was obtained with lipoteichoic acid synthesized in vivo or in vitro by differential radioisotope labeling techniques. The glycerol phosphate repeating units were transferred from phosphatidylglycerol and became linked through a phosphodiester bond to the glycerol phosphate unit of the chain farthest from or most external to the lipid end of the polymer.

摘要

来自黑曲霉的磷酸二酯酶以及高碘酸盐氧化对粪肠球菌ATCC 9790的膜脂磷壁酸进行的特异性降解表明,该分子的甘油磷酸聚合物的酶促合成是通过外部延伸系统进行的。通过体内或体外合成的脂磷壁酸,利用差异放射性同位素标记技术获得了这种机制类型的证据。甘油磷酸重复单元从磷脂酰甘油转移而来,并通过磷酸二酯键与聚合物脂质末端最远或最外部的链上的甘油磷酸单元相连。

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