McKain C W, Urban B J, Goldner J L
J Bone Joint Surg Am. 1983 Jul;65(6):808-11.
We investigated the effects of intravenous regional injection of guanethidine and reserpine in a prospective, randomized, double-blind study of seven volunteers. The sympatholytic activities of these drugs were assessed separately for cholinergic and adrenergic function. Cold challenge was employed to magnify the effect on digital temperatures and alterations in pulse-volume. Only guanethidine significantly increased temperature (p less than 0.025) after cold challenge, this effect lasting for three days. No anticholinergic effect was found. Intravenous regional guanethidine may be useful in the treatment of vasospastic disorders and as prophylaxis for surgically treated patients in whom this complication may be expected to occur.
我们在一项针对7名志愿者的前瞻性、随机、双盲研究中，调查了静脉局部注射胍乙啶和利血平的效果。分别针对胆碱能和肾上腺素能功能评估了这些药物的抗交感神经活性。采用冷刺激来放大对指端温度和脉搏容积变化的影响。冷刺激后，只有胍乙啶显著提高了温度（p<0.025），这种效果持续了三天。未发现抗胆碱能作用。静脉局部注射胍乙啶可能有助于治疗血管痉挛性疾病，并可作为预防可能发生该并发症的手术治疗患者的措施。
