低丙种球蛋白血症患者亚群的淋巴细胞在体外产生特异性抗流感病毒抗体。
Specific anti-influenza virus antibody production in vitro by lymphocytes from a subset of patients with hypogammaglobulinemia.
作者信息
Yarchoan R, Schneider H S, Wray B B, Nelson D L
出版信息
J Clin Invest. 1983 Jun;71(6):1720-7. doi: 10.1172/jci110926.
Abstract
Specific anti-influenza virus antibody production in vitro was studied in peripheral blood mononuclear cells from 17 patients with hypogammaglobulinemia. Cells obtained from 6 of 12 patients with common variable hypogammaglobulinemia produced anti-influenza virus antibody, predominantly of the IgM isotype, when cultured in vitro with type A influenza virus. No antibody was produced in vitro, however, by cells from either of two patients with Bruton's type X-linked hypogammaglobulinemia or by cells from any of three patients with X-linked hypogammaglobulinemia and isolated growth hormone deficiency. These studies demonstrate that peripheral blood mononuclear cells from a subset of patients with common variable hypogammaglobulinemia retain the potential to produce specific antibody in response to antigenic stimulation.
摘要
对17例低丙种球蛋白血症患者外周血单个核细胞体外产生特异性抗流感病毒抗体的情况进行了研究。在12例常见可变型低丙种球蛋白血症患者中，有6例患者的细胞在体外与甲型流感病毒一起培养时产生了抗流感病毒抗体，主要为IgM同种型。然而，2例Bruton型X连锁低丙种球蛋白血症患者的细胞，以及3例X连锁低丙种球蛋白血症合并孤立性生长激素缺乏患者中任何一例的细胞，在体外均未产生抗体。这些研究表明，常见可变型低丙种球蛋白血症患者亚组的外周血单个核细胞保留了在抗原刺激下产生特异性抗体的潜力。
相似文献
1
Specific anti-influenza virus antibody production in vitro by lymphocytes from a subset of patients with hypogammaglobulinemia.低丙种球蛋白血症患者亚群的淋巴细胞在体外产生特异性抗流感病毒抗体。
J Clin Invest. 1983 Jun;71(6):1720-7. doi: 10.1172/jci110926.
2
Antigen-induced suppression of human in vitro pokeweed mitogen-stimulated antibody production.抗原诱导对人体外商陆丝裂原刺激的抗体产生的抑制作用。
Cell Immunol. 1980 Sep 15;55(1):85-93. doi: 10.1016/0008-8749(80)90139-2.
3
4
Immature B cells in fetal development and immunodeficiency: studies of IgM, IgG, IgA and IgD production in vitro using Epstein-Barr virus activation.胎儿发育和免疫缺陷中的未成熟B细胞：利用爱泼斯坦-巴尔病毒激活进行体外IgM、IgG、IgA和IgD产生的研究。
Eur J Immunol. 1982 Jul;12(7):540-6. doi: 10.1002/eji.1830120703.
5
In vitro production of anti-influenza virus antibody after intranasal inoculation with cold-adapted influenza virus.经鼻内接种冷适应流感病毒后体外抗流感病毒抗体的产生
J Immunol. 1981 Nov;127(5):1958-63.
6
Humoral immunity in steroid-dependent children with asthma and hypogammaglobulinemia.患有哮喘和低丙种球蛋白血症的类固醇依赖型儿童的体液免疫
J Pediatr. 1996 Dec;129(6):898-903. doi: 10.1016/s0022-3476(96)70035-5.
7
Antibody synthesis by bone marrow cells in vitro following primary and booster tetanus toxoid immunization in humans.人体初次和加强破伤风类毒素免疫后骨髓细胞在体外的抗体合成。
J Clin Invest. 1984 May;73(5):1377-84. doi: 10.1172/JCI111341.
8
9
Defective in vitro antibody production in response to pokeweed mitogen and influenza antigen in patients with Hodgkin's disease.霍奇金病患者对商陆丝裂原和流感抗原的体外抗体产生存在缺陷。
Clin Exp Immunol. 1985 May;60(2):396-402.
10
Specific anti-influenza virus antibody production in vitro by human peripheral blood mononuclear cells.人外周血单个核细胞在体外产生特异性抗流感病毒抗体
J Immunol. 1981 Dec;127(6):2588-94.
引用本文的文献
1
Impaired antipneumococcal antibody production in patients without spleens.无脾患者抗肺炎球菌抗体产生受损。
Br Med J (Clin Res Ed). 1985 Jan 5;290(6461):14-6. doi: 10.1136/bmj.290.6461.14.
2
Mechanisms of B cell activation in patients with acquired immunodeficiency syndrome and related disorders. Contribution of antibody-producing B cells, of Epstein-Barr virus-infected B cells, and of immunoglobulin production induced by human T cell lymphotropic virus, type III/lymphadenopathy-associated virus.获得性免疫缺陷综合征及相关疾病患者B细胞活化机制。产生抗体的B细胞、爱泼斯坦-巴尔病毒感染的B细胞以及人类嗜T淋巴细胞病毒III型/淋巴结病相关病毒诱导的免疫球蛋白产生的作用。
J Clin Invest. 1986 Aug;78(2):439-47. doi: 10.1172/JCI112595.
3
Alterations in cytotoxic and helper T cell function after infection of T cell clones with human T cell leukemia virus, type I.I型人类T细胞白血病病毒感染T细胞克隆后细胞毒性和辅助性T细胞功能的改变
J Clin Invest. 1986 May;77(5):1466-73. doi: 10.1172/JCI112459.
本文引用的文献
1
In vitro production of anti-influenza virus antibody after intranasal inoculation with cold-adapted influenza virus.经鼻内接种冷适应流感病毒后体外抗流感病毒抗体的产生
J Immunol. 1981 Nov;127(5):1958-63.
2
X-linked hypogammaglobulinemia and isolated growth hormone deficiency.X连锁低丙种球蛋白血症与孤立性生长激素缺乏症。
N Engl J Med. 1980 Jun 26;302(26):1429-34. doi: 10.1056/NEJM198006263022601.
3
Specific anti-influenza virus antibody production in vitro by human peripheral blood mononuclear cells.人外周血单个核细胞在体外产生特异性抗流感病毒抗体
J Immunol. 1981 Dec;127(6):2588-94.
4
Histocompatibility requirements for T cell help in specific in vitro antibody responses to influenza virus by human blood lymphocytes.人类血液淋巴细胞对流感病毒的特异性体外抗体反应中T细胞辅助的组织相容性要求。
Eur J Immunol. 1981 Mar;11(3):206-12. doi: 10.1002/eji.1830110309.
5
Inability of patients with common variable hypogammaglobulinemia to generate lymphjoblastoid B cells following booster immunization.普通可变型免疫球蛋白缺乏症患者在加强免疫后无法产生淋巴母细胞样B细胞。
Clin Immunol Immunopathol. 1980 Jul;16(3):336-43. doi: 10.1016/0090-1229(80)90139-7.
6
Long-term human T-helper lines producing specific helper factor reactive to influenza virus.产生对流感病毒有反应的特异性辅助因子的长期人类T辅助细胞系。
Nature. 1981 Nov 12;294(5837):166-8. doi: 10.1038/294166a0.
7
Human T-cell subset requirements for the production of specific anti-influenza virus antibody in vitro.体外产生特异性抗流感病毒抗体所需的人T细胞亚群
J Clin Immunol. 1982 Apr;2(2):118-25. doi: 10.1007/BF00916895.
8
Immature B cells in fetal development and immunodeficiency: studies of IgM, IgG, IgA and IgD production in vitro using Epstein-Barr virus activation.胎儿发育和免疫缺陷中的未成熟B细胞：利用爱泼斯坦-巴尔病毒激活进行体外IgM、IgG、IgA和IgD产生的研究。
Eur J Immunol. 1982 Jul;12(7):540-6. doi: 10.1002/eji.1830120703.
9
Pathophysiologic analysis of peripheral blood lymphocytes from patients with primary immunodeficiency. I. Ig synthesis by peripheral blood lymphocytes stimulated with either pokeweed mitogen or Epstein-Barr virus in vitro.原发性免疫缺陷患者外周血淋巴细胞的病理生理分析。I. 体外经商陆有丝分裂原或爱泼斯坦-巴尔病毒刺激的外周血淋巴细胞的免疫球蛋白合成
J Immunol. 1981 Jul;127(1):311-5.
10
Three distinct stages of B-cell defects in common varied immunodeficiency.常见变异型免疫缺陷中B细胞缺陷的三个不同阶段。
Proc Natl Acad Sci U S A. 1982 Oct;79(19):6008-12. doi: 10.1073/pnas.79.19.6008.
Zotero 插件