患有哮喘和低丙种球蛋白血症的类固醇依赖型儿童的体液免疫
Humoral immunity in steroid-dependent children with asthma and hypogammaglobulinemia.
作者信息
Lack G, Ochs H D, Gelfand E W
机构信息
Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206, USA.
出版信息
J Pediatr. 1996 Dec;129(6):898-903. doi: 10.1016/s0022-3476(96)70035-5.
OBJECTIVE
To determine primary and secondary antibody responses in children with hypogammaglobulinemia attributed to corticosteroid use.
RESULTS
In seven patients with steroid-dependent asthma and significant hypogammaglobulinemia (IgG concentration, 275 to 443 mg/dl), antibody responses to protein and polysaccharide antigens were shown to be normal, as were primary and secondary responses to a neoantigen, bacteriophage phi X174.
CONCLUSIONS
Patients with asthma, and with hypogammaglobulinemia resulting from steroid therapy, have normal humoral immunity, and immunoglobulin replacement therapy is not indicated.
目的
确定因使用皮质类固醇导致低丙种球蛋白血症患儿的初次和二次抗体反应。
结果
在7例依赖类固醇的哮喘且伴有显著低丙种球蛋白血症（IgG浓度为275至443mg/dl）的患者中，对蛋白质和多糖抗原的抗体反应显示正常，对新抗原噬菌体φX174的初次和二次反应也正常。
结论
患有哮喘且因类固醇治疗导致低丙种球蛋白血症的患者具有正常的体液免疫，无需进行免疫球蛋白替代治疗。
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