Collis S C, Kimberlin R H
J Comp Pathol. 1983 Apr;93(2):331-8. doi: 10.1016/0021-9975(83)90019-1.
Previous studies showed that the concentration of IgG in serum was increased in a high proportion of Herdwick sheep in the clinical stage of natural scrapie. The present paper reports similar findings in Herdwicks with experimental scrapie in which the clinical signs were different. Further studies of the natural disease showed increased concentrations of IgG in CSF due to passive filtration from serum and not to local antibody production in the CNS. Qualitative differences in serum IgG have also been found in natural scrapie, involving a shift in the major IgG isotype from IgG1 to IgG2. The significance of these changes is not known but the limited evidence available may indicate a progressive dysfunction in certain sub-populations of lymphocytes in sheep scrapie.
先前的研究表明，在自然感染羊瘙痒病临床阶段的很大一部分赫德威克绵羊中，血清中IgG浓度升高。本文报道了患有实验性羊瘙痒病的赫德威克绵羊也有类似发现，不过其临床症状有所不同。对自然发病情况的进一步研究表明，脑脊液中IgG浓度升高是由于血清被动滤过所致，而非中枢神经系统局部产生抗体。在自然感染羊瘙痒病中还发现血清IgG存在定性差异，主要IgG同种型从IgG1转变为IgG2。这些变化的意义尚不清楚，但现有有限证据可能表明绵羊瘙痒病中某些淋巴细胞亚群存在进行性功能障碍。
