Kohane I, Kidwell J F
J Hered. 1983 May-Jun;74(3):175-80. doi: 10.1093/oxfordjournals.jhered.a109757.
One-, two- and three-locus models of selection and mutation in completely self-fertilizing populations are examined. Equilibrium frequencies can be determined for these systems. Numerical analyses indicate that random genetic drift attributable to selfing plays a major role in determining equilibrium frequencies, even when strong directional selection is operating. Linkage has no effect on marginal gene frequencies or single-locus heterozygosity at equilibrium. The only model of those examined which leads to linkage disequilibrium is disruptive selection. In that model, selection reinforced the effect of selfing in favoring the homozygous genotypes.
本文研究了完全自花授粉群体中选择和突变的单基因座、双基因座及三基因座模型。可以确定这些系统的平衡频率。数值分析表明，即使存在强烈的定向选择，自交引起的随机遗传漂变在决定平衡频率方面仍起主要作用。连锁对平衡时的边际基因频率或单基因座杂合性没有影响。在所研究的模型中，唯一导致连锁不平衡的是分裂选择。在该模型中，选择增强了自交对纯合基因型的偏好作用。
