Brown J W, Grober E
J Nerv Ment Dis. 1983 Jul;171(7):431-4.
The incidence of motor and sensory, (nonfluent and fluent) aphasia was studied in 389 patients with a left-sided vascular lesion. The mean age of patients with motor aphasia was 45.3 years, and the mean age of patients with sensory aphasia was 56.5 years. The age difference was also found in a separate analysis of 50 cases of traumatic aphasia. Nonfluent aphasias predominate in early life in both males and females, but are more common in females in the third decade. The relationship between aphasia type and age, and sex, is explained by a process of regional specification of the left language areas that proceeds more slowly in females than males. It is hypothesized that this process reflects the effects of the sex hormones on protein synthesis and brain growth.
对389例左侧血管病变患者的运动性和感觉性（非流利型和流利型）失语症发病率进行了研究。运动性失语症患者的平均年龄为45.3岁，感觉性失语症患者的平均年龄为56.5岁。在对50例创伤性失语症的单独分析中也发现了年龄差异。非流利型失语症在男性和女性的早期生活中占主导地位，但在第三个十年中在女性中更为常见。失语症类型与年龄和性别的关系可以通过左侧语言区域的区域特化过程来解释，该过程在女性中比男性进展得更慢。据推测，这个过程反映了性激素对蛋白质合成和大脑生长的影响。
