Altura B M, Altura B T, Carella A
Science. 1983 Jul 22;221(4608):376-8. doi: 10.1126/science.6867714.
Isolated umbilical arteries and veins, obtained from normal women at the end of pregnancy, were incubated in krebs-Ringer bicarbonate solution and exposed to magnesium at concentrations ranging from 0 to 9.6 millimoles per liter. The basal tension of the vessels increased when magnesium was withdrawn and decreased when the concentration of magnesium was raised. Absence of magnesium in the medium significantly potentiated the contractile response of the vessels to bradykinin, angiotensin II, serotonin, and prostaglandin F2 alpha. It appears that magnesium deficiency may be responsible for spasms of umbilical and placental vasculature. Our findings may provide a rationale for why magnesium sulfate is an effective therapy in preeclamptic syndromes in pregnant women.
从正常孕妇妊娠末期获取的孤立脐动脉和脐静脉，置于 Krebs - Ringer 碳酸氢盐溶液中，并暴露于浓度范围为 0 至 9.6 毫摩尔/升的镁中。去除镁时血管的基础张力增加，而提高镁浓度时基础张力降低。培养基中缺乏镁会显著增强血管对缓激肽、血管紧张素 II、血清素和前列腺素 F2α 的收缩反应。镁缺乏似乎可能是脐血管和胎盘血管痉挛的原因。我们的研究结果可能为硫酸镁为何是治疗孕妇先兆子痫综合征的有效疗法提供了理论依据。
