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存在于人类脑脊液中的单胺氧化酶内源性抑制剂。

Endogenous inhibitors of monoamine oxidase present in human cerebrospinal fluid.

作者信息

Becker R E, Giambalvo C, Fox R A, Macho M

出版信息

Science. 1983 Jul 29;221(4609):476-8. doi: 10.1126/science.6867724.

DOI:10.1126/science.6867724
PMID:6867724
Abstract

Inhibitory activity against the enzyme monoamine oxidase is present in low molecular weight fractions (less than 100,000) of human cerebrospinal fluid. These endogenous substances of different molecular weights (3000 to more than 35,000) act like monoamine oxidase inhibitor drugs to inhibit both type A and type B monoamine oxidase.

摘要

人脑脊液的低分子量组分（小于100,000）中存在对单胺氧化酶的抑制活性。这些不同分子量（3000至超过35,000）的内源性物质的作用类似于单胺氧化酶抑制药物，可抑制A型和B型单胺氧化酶。

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引用本文的文献

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90 years of monoamine oxidase: some progress and some confusion.90 年的单胺氧化酶：一些进展和一些困惑。
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The stress-induced reduction in monoamine oxidase (MAO) A activity is reversed by benzodiazepines: role of peripheral benzodiazepine receptors.苯二氮䓬类药物可逆转应激诱导的单胺氧化酶（MAO）A活性降低：外周苯二氮䓬受体的作用
Cell Mol Neurobiol. 1993 Dec;13(6):593-600. doi: 10.1007/BF00711559.
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Effect of neurocatin on the activity of monoamine oxidase B in rat brain synaptosomes.
神经抑素对大鼠脑突触体中单胺氧化酶B活性的影响。
Neurochem Res. 1994 Feb;19(2):177-82. doi: 10.1007/BF00966813.
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J Neural Transm. 1987;69(3-4):229-42. doi: 10.1007/BF01244344.
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Potentiation by deprenyl of the autoreceptor-mediated inhibition of [3H]-5-hydroxytryptamine release by 5-methoxytryptamine.司来吉兰对5-甲氧基色胺通过自身受体介导抑制[3H]-5-羟色胺释放的增强作用。
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