Dajani E Z, Driskill D R
Arch Int Pharmacodyn Ther. 1978 Jun;233(2):243-50.
The gastric antisecretory efficacy of propantheline bromide (PB) as a function of the route of administration was studied in dogs equipped with chronic gastric fistulae. Sectetion was near-maximally stimulated by continuous intravenous (i.v.) infusion of pentagastrin. PB was administered either intragastrically (i.g.) or intravenously as a single bolus dose at the steady-state plateau of gastric secretion. The administration of PB produced a dose-dependent inhibition of gastric secretion (water and acid output). Gastric acid concentration was not appreciably inhibited by PB. The dose-response (inhibition of acid output) curves for i.g. and i.v. administered PB were parallel. The potency (fiducial limits) of i.v. relative to i.g. administration was found to be 0.002 (0,0006--0,0051) when the i.v. value was taken as unity.
在装有慢性胃瘘的犬中研究了溴丙胺太林（PB）的胃抗分泌功效与给药途径的关系。通过持续静脉输注五肽胃泌素使分泌接近最大程度地受到刺激。在胃分泌的稳态平台期，PB以单次推注剂量经胃内（i.g.）或静脉内给药。PB的给药产生了剂量依赖性的胃分泌抑制（水和酸分泌量）。PB对胃酸浓度没有明显抑制作用。经胃内和静脉内给药的PB的剂量-反应（酸分泌量抑制）曲线是平行的。当将静脉内给药的值视为1时，发现静脉内给药相对于经胃内给药的效力（置信限）为0.002（0.0006 - 0.0051）。
