Crowley L V, Olson R W
Am J Gastroenterol. 1983 Jul;78(7):406-10.
A megaloblastic anemia occurred in a middle-aged woman 6 years after a gastric bypass performed for obesity. Marked deficiencies of both vitamin B12 and folic acid were demonstrated. The Schilling test revealed that the vitamin B12 deficiency was due primarily to inadequate intrinsic factor. Vitamin and mineral deficiencies are relatively common long-term complications in gastric bypass patients, and result from multiple factors including restricted food intake, inadequate gastric digestion, and inadequate intrinsic factor. Bypass patients should receive vitamin-mineral supplements routinely and should have long-term periodic clinical and laboratory evaluation in order to prevent late hematological complications.
一名中年女性在因肥胖接受胃旁路手术后6年出现巨幼细胞贫血。维生素B12和叶酸均显著缺乏。希林试验显示维生素B12缺乏主要是由于内因子不足。维生素和矿物质缺乏是胃旁路手术患者相对常见的长期并发症，由多种因素导致，包括食物摄入量受限、胃消化不足和内因子不足。接受胃旁路手术的患者应常规接受维生素矿物质补充剂，并应进行长期定期临床和实验室评估，以预防晚期血液学并发症。
