May P R, Van Putten T, Jenden D J, Cho A K
Arch Gen Psychiatry. 1978 Sep;35(9):1091-7. doi: 10.1001/archpsyc.1978.01770330065005.
A gas chromatographic/mass spectrometric method for measuring chlorpromazine using 2H6--labeled chlorpromazine as an internal standard has the potential for considerable precision and specificity. Results are reported of chlorpromazine levels in plasma and saliva after administration of a single test dose to 13 schizophrenic patients in a tightly designed experiment. There was a clear and substantive relationship between blood and saliva levels of chlorpromazine, both following a typical decay curve. Saliva and plasma levels were strongly associated for a particular patient, and there was even a strong consistency in saliva-plasma ratios between patients, with an overall statistically significant correlation between plasma and saliva levels for all measurement on all 13 patients. In general, it seems that saliva sampling has great potential as a simple noninvasive technique for investigation of chlorpromazine and other antipsychotic drugs in psychotic patients. Nevertheless, for the moment, it should be regarded as strictly experimental and not suitable for immediate clinical application.
一种以2H6标记的氯丙嗪为内标物测定氯丙嗪的气相色谱/质谱法具有相当高的精密度和特异性。在一项设计严谨的实验中，对13名精神分裂症患者单次给予测试剂量后，报告了血浆和唾液中氯丙嗪的水平。氯丙嗪的血液和唾液水平之间存在明显且实质性的关系，两者均遵循典型的衰减曲线。对于特定患者，唾液和血浆水平密切相关，患者之间唾液-血浆比值甚至具有很强的一致性，对所有13名患者的所有测量中，血浆和唾液水平总体上具有统计学显著相关性。一般来说，唾液采样作为一种简单的非侵入性技术，在研究精神病患者的氯丙嗪和其他抗精神病药物方面似乎具有很大潜力。然而，目前，它应被视为严格的实验性方法，不适用于即时临床应用。
