嗅神经母细胞瘤分泌精氨酸加压素导致可逆性抗利尿综合征。

Neurosecretion of arginine vasopressin by an olfactory neuroblastoma causing reversible syndrome of antidiuresis.

作者信息

Cullen M J, Cusack D A, O'Briain D S, Devlin J B, Kehely A, Lyons T A

出版信息

Am J Med. 1986 Nov;81(5):911-6. doi: 10.1016/0002-9343(86)90368-2.

Abstract

A 26-year-old woman with the syndrome of inappropriate antidiuresis demonstrated complete recovery following the resection of an olfactory neuroblastoma. Tissue arginine vasopressin levels by radioimmunoassay, immunohistochemical staining of the tissue arginine vasopressin, postoperative normalization of plasma arginine vasopressin levels, and the clinical resolution are evidence in support of a neurally derived tumor being the direct source of neurosecretion of arginine vasopressin rather than neurohypophyseal secretion or secretion from non-neural tissues, as reported to date in the etiology of the syndrome of inappropriate antidiuresis.

摘要

一名患有抗利尿激素分泌异常综合征的26岁女性在切除嗅神经母细胞瘤后完全康复。通过放射免疫测定法检测组织中精氨酸加压素水平、对组织精氨酸加压素进行免疫组织化学染色、术后血浆精氨酸加压素水平恢复正常以及临床症状缓解，这些证据支持神经源性肿瘤是精氨酸加压素神经分泌的直接来源，而非如迄今报道的抗利尿激素分泌异常综合征病因中所述的神经垂体分泌或非神经组织分泌。