Whiting P H, Simpson J G
Biochem Pharmacol. 1983 Jul 1;32(13):2025-8. doi: 10.1016/0006-2952(83)90422-7.
Normal rats receiving treatment with either cyclosporin A or gentamicin show dose-dependent nephrotoxicity, the changes with cyclosporin A centering on the straight segment of the proximal tubule, while gentamicin affects the convoluted segment. When the two drugs are given together, nephrotoxicity is enhanced with significant reductions in renal function even at therapeutic dosage. The study emphasises the caution needed when potentially nephrotoxic agents are administered in combination.
接受环孢素A或庆大霉素治疗的正常大鼠表现出剂量依赖性肾毒性，环孢素A引起的变化主要集中在近端小管的直段，而庆大霉素则影响曲段。当两种药物联合使用时，即使在治疗剂量下，肾毒性也会增强，肾功能会显著降低。该研究强调了联合使用潜在肾毒性药物时需要谨慎。
