John L R, Marsh G M, Enterline P E
Br J Ind Med. 1983 Aug;40(3):346-52. doi: 10.1136/oem.40.3.346.
A comparative study was conducted to assess empirically the suspected bias associated with occupational health studies based only on information obtainable from employers' records. Standardised mortality ratios were extracted from five occupational cohorts for which extensive follow up had been conducted and were compared with proportional mortality ratios based on deaths known (KTE) and unknown (UTE) to the employer, and on total deaths. For the five cohorts examined the suspected bias for the cause of death categories all cancer, respiratory cancer, heart disease, and accidents was generally found to be minimal unless the number of UTE deaths was in excess of 75%. Furthermore, a strong inverse relationship was observed between the percentage of UTE deaths and the level of agreement between proportional mortality ratios based on KTE deaths and total deaths. In partial support of these findings it was also observed that workers who left the industry in three of the five cohorts subsequently experienced similar overall mortality compared with those who continued employment. These findings should serve as a rough indication of the potential value of estimating disease risks from KTE deaths and serve as a guide for other investigators using limited data.
开展了一项比较研究,以实证评估仅基于从雇主记录中获取的信息的职业健康研究中存在的可疑偏差。从五个职业队列中提取了标准化死亡率,这些队列进行了广泛的随访,并将其与基于雇主已知(KTE)和未知(UTE)死亡人数以及总死亡人数的比例死亡率进行了比较。对于所检查的五个队列,除非UTE死亡人数超过75%,否则通常发现所有癌症、呼吸道癌症、心脏病和事故等死亡原因类别的可疑偏差极小。此外,还观察到UTE死亡百分比与基于KTE死亡人数和总死亡人数的比例死亡率之间的一致性水平呈强烈负相关。部分支持这些发现的是,还观察到在五个队列中的三个队列中离开该行业的工人与继续就业的工人随后经历了相似的总体死亡率。这些发现应作为从KTE死亡人数估计疾病风险的潜在价值的粗略指标,并为其他使用有限数据的研究人员提供指导。