Aspillaga M O, Whittaker P G, Taylor A, Lind T
Br J Obstet Gynaecol. 1983 Jul;90(7):596-603. doi: 10.1111/j.1471-0528.1983.tb09274.x.
Serial measurements of serum progesterone, oestradiol, prolactin, human chorionic gonadotrophin (hCG) and human placental lactogen (hPL) have been determined in 32 healthy women at regular intervals throughout pregnancy. The data confirm previous reports that levels of these hormones vary widely between individuals at each stage of gestation, but further analyses have shown two other features: first there is a clear tendency for individuals to retain their rank in the spectrum of hormone values throughout pregnancy; second when the concentrations of the individual hormones (except hCG) are transformed to logarithmic values, the trends within individuals approximate well to straight lines during the second and third trimester of pregnancy. These findings provide a relatively simple method for describing the rates of change in the concentrations of these hormones and for examining possible relations between them. They also suggest that the quality of the maternal endocrine milieu may be determined at an early stage of gestation.
对32名健康女性在整个孕期定期进行血清孕酮、雌二醇、催乳素、人绒毛膜促性腺激素（hCG）和人胎盘催乳素（hPL）的系列测定。数据证实了先前的报道，即在妊娠各阶段，这些激素水平在个体之间差异很大，但进一步分析显示了另外两个特征：第一，个体在整个孕期激素值谱中的排名有明显的保持趋势；第二，当将个体激素（hCG除外）的浓度转换为对数值时，在妊娠中期和晚期个体内的变化趋势非常接近直线。这些发现为描述这些激素浓度的变化率以及研究它们之间可能的关系提供了一种相对简单的方法。它们还表明，母体内分泌环境的质量可能在妊娠早期就已确定。
