Garg K, Sujata P, Kumari G L, Pandey P K, Padubidri V, Anand C
Department of Anatomy and Obstetrics and Gynecology, Lady Hardinge Medical College, New Delhi, India.
J Endocrinol Invest. 1993 Apr;16(4):247-51. doi: 10.1007/BF03348822.
Serial changes in the endometrial levels of estrogen and progesterone receptors (ER and PR) were measured in 50 women from days 2 to 14 of missed menses and correlated with the plasma concentrations of hCG, progesterone and 17 beta-estradiol. Both ER and PR of nuclei were higher than cytosolic proteins, with a shift in the ratio of nER/nPR to nPR from 4th day after missed menses. On Scatchard analysis of the cytosolic and nuclear binding proteins, two classes of proteins, corresponding to Type I and II, were found. While the increasing levels of hCG maintained luteal secretion of progesterone and 17 beta-estradiol at normal mid-luteal phase levels, a gradual increase in 17 beta estradiol from 9th day of missed menses was noted. This delicate balance between circulating levels of progesterone and 17 beta-estradiol and their nuclear receptors at early stages of pregnancy may be of significance.
在50名女性中，测定了从月经推迟第2天到第14天子宫内膜中雌激素和孕激素受体（ER和PR）的系列变化，并将其与血浆中hCG、孕激素和17β-雌二醇的浓度进行关联。细胞核的ER和PR均高于胞质蛋白，月经推迟后第4天nER/nPR与nPR的比值发生变化。对胞质和核结合蛋白进行Scatchard分析时，发现了两类对应于I型和II型的蛋白。虽然hCG水平升高使孕激素和17β-雌二醇的黄体分泌维持在正常黄体中期水平，但在月经推迟第9天开始观察到17β-雌二醇逐渐增加。妊娠早期循环中的孕激素和17β-雌二醇水平及其核受体之间的这种微妙平衡可能具有重要意义。
