Hirono I, Aiso S, Hosaka S, Yamaji T, Haga M
Carcinogenesis. 1983;4(7):885-7. doi: 10.1093/carcin/4.7.885.
Fifteen male and 15 female Charles River Sprague-Dawley rats (CD rats) of 6 weeks old were given a diet containing 30% bracken fronds throughout the experimental period of 260 days. Male rats fed bracken diet developed multiple ileal tumors and urinary bladder tumors with incidences of 100% and 60%, respectively. Female rats developed multiple mammary tumors with an incidence of 87% in addition to ileal and urinary bladder tumors. The earliest mammary tumor was detected on day 78, and the last on day 256. The average number of tumors per rat was 5.6. Most mammary tumors were papillary carcinomas and adenocarcinomas. No tumors were found in rats in the control group.
15只6周龄雄性和15只6周龄雌性查尔斯河斯普拉格-道利大鼠（CD大鼠）在260天的实验期内喂食含30%蕨叶的饲料。喂食蕨类饲料的雄性大鼠发生多发性回肠肿瘤和膀胱肿瘤，发病率分别为100%和60%。雌性大鼠除发生回肠和膀胱肿瘤外，还发生多发性乳腺肿瘤，发病率为87%。最早的乳腺肿瘤在第78天被检测到，最晚的在第256天被检测到。每只大鼠的平均肿瘤数为5.6个。大多数乳腺肿瘤为乳头状癌和腺癌。对照组大鼠未发现肿瘤。
