核小体在DNA上的特定排列与嘌呤 - 嘧啶和嘧啶 - 嘌呤二聚体的周期性分布相关。
Specific alignment of nucleosomes on DNA correlates with periodic distribution of purine-pyrimidine and pyrimidine-purine dimers.
作者信息
Zhurkin V B
出版信息
FEBS Lett. 1983 Jul 25;158(2):293-7. doi: 10.1016/0014-5793(83)80598-5.
PMID:6873283
Abstract
Comparison of the X-ray data and results of conformational analysis reveals the sequence-dependent helical anisotrophy of DNA: purine-pyrimidine (RY) and pyrimidine-purine (YR) dimers prefer bending in the opposite directions. On this basis it is suggested that in the optimal nucleosomal DNA sequence the RY and YR dinucleotides alternate at intervals of 5-6 basepairs. Examination of the cases with the known disposition of nucleosomes confirms this concept.
摘要
X射线数据与构象分析结果的比较揭示了DNA序列依赖性的螺旋各向异性：嘌呤-嘧啶（RY）和嘧啶-嘌呤（YR）二聚体倾向于向相反方向弯曲。在此基础上，有人提出，在最佳核小体DNA序列中，RY和YR二核苷酸以5至6个碱基对的间隔交替出现。对已知核小体排列情况的实例进行检查证实了这一概念。
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