Guibout M, Jaquet P, Lissitzky J C, Grisoli F, Vincentelli F
Ann Endocrinol (Paris). 1978;39(2):95-106.
Among 18 patients suffering prolactin adenoma and 16 acromegalic patients, plasma levels of PRL and HGH respectively returned to normal vlues (PRL = 9 +/- 2 ng/ml HGH = 4.2 +/- 0.8 ng/ml) immediately after selective removal of the pituitary adenoma by transsphenoïdal route. In all cases tumoral symptoms were reduced. Menses were recovered 36 +/- 5 days after surgery in all patients with prolactin adenoma. Pregnancy succeeded in nine of these women. Per-operative studies of HGH and PRL plasma variations proved to be of good prognostic value. The evaluation of the pituitary functions was performed before and after surgery. In no case pituitary deficiency occured after treatment. Furthermore the regulation of somatotropic and prolactin functions have been documented by the use of different provocative tests before and after treatment. They allow discussion of the pathogenecity of these hypersecreting tumors.
在18例催乳素腺瘤患者和16例肢端肥大症患者中，经蝶窦途径选择性切除垂体腺瘤后，血浆PRL和HGH水平分别立即恢复正常（PRL = 9 ± 2 ng/ml，HGH = 4.2 ± 0.8 ng/ml）。所有病例的肿瘤症状均减轻。所有催乳素腺瘤患者术后36 ± 5天月经恢复。其中9名女性成功怀孕。术中对HGH和PRL血浆变化的研究证明具有良好的预后价值。在手术前后对垂体功能进行了评估。治疗后无一例出现垂体功能减退。此外，通过治疗前后使用不同的激发试验记录了生长激素和催乳素功能的调节情况。这些试验有助于探讨这些分泌过多肿瘤的发病机制。
