Miserocchi G, Negrini D, Mariani E, Passafaro M
J Appl Physiol Respir Environ Exerc Physiol. 1983 Jun;54(6):1574-8. doi: 10.1152/jappl.1983.54.6.1574.
In supine rabbits injection of 2 ml of saline into the lower right diaphragmatic region increased pleural liquid pressure at the injection point and, to a minor extent, on the costal and mediastinal side, indicating a redistribution of liquid among the pleural compartments. Over a period of 120 min end-expiratory liquid pressure on the diaphragmatic and costal surfaces approached the control value as a result of local reabsorption. No difference in the time course of liquid pressure was found on injection of either saline or homologous plasma. This was confirmed by measuring the volume of saline or plasma remaining in the cavity 90 min after injection; the net absorption flow amounted to 0.22 ml . kg-1 . h-1. These results suggest that local absorption mechanisms are relatively independent of the Starling pressure gradients acting across the pulmonary-perfused (-10.2 and 6.6 cmH2O with saline and plasma, respectively, the negative sign indicating a reabsorption gradient) and systemically perfused mesothelium (3.3 and 20.1 cmH2O with saline and plasma, respectively).
在仰卧的兔子右下膈肌区域注射2 ml生理盐水，注射点处的胸腔液体压力升高，在肋侧和纵隔侧也有轻微升高，这表明液体在胸腔各腔室间重新分布。在120分钟内，由于局部重吸收，膈肌表面和肋表面的呼气末液体压力接近对照值。注射生理盐水或同源血浆后，液体压力的时间进程没有差异。注射90分钟后测量胸腔内剩余的生理盐水或血浆体积，证实了这一点；净吸收流量为0.22 ml·kg-1·h-1。这些结果表明，局部吸收机制相对独立于跨肺灌注（生理盐水和血浆分别为-10.2和6.6 cmH2O，负号表示重吸收梯度）和全身灌注间皮（生理盐水和血浆分别为3.3和20.1 cmH2O）的Starling压力梯度。
