Ennever J F, McDonagh A F, Speck W T
J Pediatr. 1983 Aug;103(2):295-9. doi: 10.1016/s0022-3476(83)80370-9.
Phototherapy results in transformation of bilirubin to more water-soluble isomers. The efficacy of monochromatic visible light from 350 to 550 nm in the fastest photoisomerization reaction was quantitated by high-pressure liquid chromatography. The most effective wavelengths in vitro (i.e., leading to greater than 25% photoisomer) were in the blue spectrum from approximately 390 to 470 nm. Green light (530 nm) was not only ineffective for production of photoisomer, but capable of reversing the reaction. The results indicate that any clinically useful phototherapy unit must include the blue portion of the visible spectrum, and suggest that the effectiveness of phototherapy may be increased by elimination of green light.
光疗可使胆红素转化为水溶性更高的异构体。通过高压液相色谱法对350至550纳米的单色可见光在最快光异构化反应中的功效进行了定量分析。体外最有效的波长（即导致光异构化大于25%）在约390至470纳米的蓝光光谱范围内。绿光（530纳米）不仅对光异构体的产生无效，而且能够逆转该反应。结果表明，任何临床上有用的光疗设备都必须包括可见光谱的蓝光部分，并表明通过消除绿光可能会提高光疗的效果。
