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蓝光照射及联合蓝光照射/药物处理对 U937 细胞增殖的抑制作用

Inhibition of Proliferation in U937 Cells Treated by Blue Light Irradiation and Combined Blue Light Irradiation/Drug.

机构信息

State Key Laboratory of Superhard Materials, Jilin University, Changchun 130012, China.

出版信息

Int J Mol Sci. 2018 May 15;19(5):1464. doi: 10.3390/ijms19051464.

DOI:10.3390/ijms19051464
PMID:29762467
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5983758/
Abstract

The cell viability and apoptosis of tumor U937 cells treated by blue light (BL) irradiation have been examined. BL irradiation can specially inhibit the proliferation and promote the apoptosis of U937 cells, relating to the production of reactive oxygen species (ROS) and the decline of mitochondrial membrane potential (ΔΨm). The apoptosis is further associated with varying downregulated () and () genes, upregulated () gene, the activation of caspase-3 and caspase-9, and the cleavage of poly (ADP-ribose) polymerase (PARP) by the BL irradiation process. Moreover, BL irradiation induced proliferation inhibition is higher than that treated by a common chemotherapeutic drug of homoharringtonine (HHT). When we synergize BL irradiation with HHT (BL-HHT), a higher proliferation inhibition is obtained than that treated by BL irradiation or HHT alone. These results are helpful for establishing a low toxicity and high efficiency strategy of BL irradiation for clinical treatment of acute myeloid leukemia, not limited to U937 cells.

摘要

已检测到蓝光 (BL) 照射处理的肿瘤 U937 细胞的细胞活力和细胞凋亡。BL 照射可特异性抑制 U937 细胞的增殖并促进其凋亡，这与活性氧 (ROS) 的产生和线粒体膜电位 (ΔΨm) 的下降有关。凋亡还与不同下调的 () 和 () 基因、上调的 () 基因、caspase-3 和 caspase-9 的激活以及 BL 照射过程中聚 (ADP-核糖) 聚合酶 (PARP) 的裂解有关。此外，BL 照射诱导的增殖抑制作用高于常用化疗药物高三尖杉酯碱 (HHT) 的作用。当我们将 BL 照射与 HHT (BL-HHT) 联合使用时，与单独使用 BL 照射或 HHT 相比，获得了更高的增殖抑制作用。这些结果有助于建立 BL 照射治疗急性髓细胞白血病的低毒性和高效策略，不仅限于 U937 细胞。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/845d/5983758/050fb6551c07/ijms-19-01464-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/845d/5983758/03d80081b726/ijms-19-01464-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/845d/5983758/d3b234cebb20/ijms-19-01464-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/845d/5983758/12692615a6ca/ijms-19-01464-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/845d/5983758/ef8f139c1829/ijms-19-01464-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/845d/5983758/5d4512ab1d79/ijms-19-01464-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/845d/5983758/050fb6551c07/ijms-19-01464-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/845d/5983758/03d80081b726/ijms-19-01464-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/845d/5983758/d3b234cebb20/ijms-19-01464-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/845d/5983758/12692615a6ca/ijms-19-01464-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/845d/5983758/ef8f139c1829/ijms-19-01464-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/845d/5983758/5d4512ab1d79/ijms-19-01464-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/845d/5983758/050fb6551c07/ijms-19-01464-g006.jpg

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2
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Photochem Photobiol Sci. 2016 May 11;15(5):644-53. doi: 10.1039/c5pp00424a. Epub 2016 Apr 21.
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PLoS One. 2023 Feb 2;18(2):e0281062. doi: 10.1371/journal.pone.0281062. eCollection 2023.
4
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RSC Adv. 2019 Nov 28;9(67):39124-39132. doi: 10.1039/c9ra08049j. eCollection 2019 Nov 27.
5
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Antioxidants (Basel). 2022 Mar 31;11(4):683. doi: 10.3390/antiox11040683.
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