Ziegler E E, Fomon S J
J Pediatr Gastroenterol Nutr. 1983 May;2(2):288-94.
To determine if lactose promotes the intestinal absorption of calcium and other minerals by infants, metabolic balance studies were performed with infants fed two formulas nearly identical in composition except for carbohydrate. One contained only lactose and the other contained sucrose and corn starch hydrolysate. Each of six normal infants had two balance studies performed with each formula in alternating sequence. When lactose was the carbohydrate, net absorption and net retention of calcium were significantly greater than when lactose was not present in the formula. Absorptions of magnesium and manganese were also significantly enhanced by lactose. Absorptions of copper and zinc were somewhat greater (not statistically significant) when lactose was present, whereas absorption of iron was not affected. Absorption of phosphorus was not different, but urinary excretion was less when the lactose containing formula was fed and, hence, net retention of phosphorus was significantly enhanced. These results confirm findings from animal studies and previous human studies and show that, in infants, lactose has a significant and sustained promoting effect on absorption of calcium and other minerals.
为了确定乳糖是否能促进婴儿肠道对钙及其他矿物质的吸收，对两组婴儿进行了代谢平衡研究。这两组婴儿喂食的两种配方奶粉除碳水化合物外成分几乎相同。一种配方奶粉仅含乳糖，另一种含蔗糖和玉米淀粉水解物。六名正常婴儿每人都交替使用这两种配方奶粉进行了两项平衡研究。当碳水化合物为乳糖时，钙的净吸收量和净保留量显著高于配方奶粉中不含乳糖时。乳糖也显著增强了镁和锰的吸收。当存在乳糖时，铜和锌的吸收量有所增加（无统计学意义），而铁的吸收不受影响。磷的吸收没有差异，但喂食含乳糖配方奶粉时尿排泄量较少，因此磷的净保留量显著增加。这些结果证实了动物研究和以往人体研究的结果，表明在婴儿中，乳糖对钙和其他矿物质的吸收具有显著且持续的促进作用。
