Stupakov G P, Kazeĭkin V S, Volozhin A I
Kosm Biol Aviakosm Med. 1983 May-Jun;17(3):36-45.
The rate of atrophic changes in spongy bones of the weightless man was estimated, using studies of human, dog and rat bones, as well as observations of neurological patients bed-stricken for a long time. Taking into consideration data on the literature on the bone status and mineral balance in real and simulated space flights, two models were built. The models make it possible to estimate osteoporosis of spongy bones of the axial skeleton in the absence of weight loading. One of the models--an intraspecies model for the human population--is based on the experimentally found rate of the physiological rearrangement of various spongy bones. The other--interspecies--model is built with reference to the parameters determining the rate, i. e. bone density and metabolism. The average monthly rates of axial bone losses calculated by means of the two independent methods are essentially identical. The data obtained allow prediction of the decrease of tolerance to head-to-feet impact acceleration as a function of flight duration.
利用对人类、狗和大鼠骨骼的研究以及对长期卧床的神经疾病患者的观察，估算了失重状态下人体松质骨的萎缩变化率。考虑到有关实际和模拟太空飞行中骨骼状态和矿物质平衡的文献数据，构建了两个模型。这些模型能够在无重量负荷的情况下估算中轴骨骼松质骨的骨质疏松情况。其中一个模型——人类种群的种内模型——基于通过实验发现的各种松质骨生理重塑率。另一个模型——种间模型——是参照决定该速率的参数构建的，即骨密度和新陈代谢。通过这两种独立方法计算出的中轴骨平均每月流失率基本相同。所获得的数据能够预测耐受头脚向冲击加速度的能力随飞行持续时间的下降情况。
