Chopp M, Portnoy H D, Branch C
Neurosurgery. 1983 Jul;13(1):5-11. doi: 10.1227/00006123-198307000-00002.
A hydraulic model of the cerebrovascular bed is presented. The model consists of a Starling resistor in series with an upstream resistance. Volume-pressure tests were performed on the model by injecting fluid into the rigid shell of the Starling resistor. An exponential pressure response to the increase in fluid volume was observed, which supports the hypothesis that the origin of the in vivo exponential pressure response to a transient increase in cerebrospinal fluid (CSF) volume can be attributed to compression of the cerebral vessels, most probably the veins. Mathematical expressions for the dependence of pressure on volume change were derived from the model and applied to in vivo volume-pressure data. The correlation between the model and in vivo experiments suggests that the CSF pressure is coupled to cerebral venous pressure and that the volume-pressure test is an indirect measure of the cerebral venous volume and is not a measure of intracranial elastance. The physical basis for the volume-pressure test is clarified, and expressions are derived to improve the utility of the test.
本文提出了一种脑血管床的水力模型。该模型由一个与上游阻力串联的斯塔林电阻器组成。通过向斯塔林电阻器的刚性外壳中注入液体，对该模型进行了体积-压力测试。观察到对液体体积增加的指数压力响应，这支持了以下假设：体内对脑脊液（CSF）体积短暂增加的指数压力响应的起源可归因于脑血管，很可能是静脉的压缩。从该模型推导出压力对体积变化的依赖关系的数学表达式，并将其应用于体内体积-压力数据。模型与体内实验之间的相关性表明，脑脊液压力与脑静脉压力相关，并且体积-压力测试是脑静脉体积的间接测量方法，而不是颅内弹性的测量方法。阐明了体积-压力测试的物理基础，并推导了表达式以提高该测试的实用性。
