Mathias R T
Biophys J. 1978 Aug;23(2):277-84. doi: 10.1016/S0006-3495(78)85448-4.
The linear electrical properties of skeletal muscle fibers have been analyzed using lumped circuit analogues of helicoidal T system. The geometry of a helicoid is assumed to produce two electrical effects, modeled separately. One model is motivated by the pitch or tilt of the T system, which forces the current flowing in the lumen of the tubules to have a longitudinal projection. The second model is motivated by the longitudinal continuity of a helicoid, which forms a structure similar to a cable within the fiber. The pitch or tilting of the T system plane modified the longitudinal resistance of the fiber, making it slightly frequency dependent; however, the magnitude of the change was less than 0.1%. The longitudinal connections between T system networks had a more complicated effect; the magnitude of the correction was again less than 0.1%. The conclusion from this analysis is that a helicoidal T system, whose pitch is constrained by the sarcomere spacing, will not affect electrical signals recorded intracellularly in intact fibers.
利用螺旋形T系统的集总电路模拟，对骨骼肌纤维的线性电学特性进行了分析。假设螺旋体的几何形状会产生两种电学效应，并分别进行建模。一种模型是由T系统的螺距或倾斜度驱动的，它迫使在小管腔内流动的电流具有纵向投影。第二种模型是由螺旋体的纵向连续性驱动的，它在纤维内形成了一种类似于电缆的结构。T系统平面的螺距或倾斜度改变了纤维的纵向电阻，使其略微依赖于频率；然而，变化幅度小于0.1%。T系统网络之间的纵向连接产生了更复杂的影响；校正幅度同样小于0.1%。该分析的结论是，螺距受肌节间距限制的螺旋形T系统不会影响在完整纤维中细胞内记录的电信号。
