Baulac M, Rieger F, Meininger V
Neurosci Lett. 1983 May 27;37(1):99-104. doi: 10.1016/0304-3940(83)90511-6.
The spinal motorneuronal pools specific to a peripheral muscular territory were studied in the wobbler mutant mouse, with the use of retrograde transport of horseradish peroxidase, which was injected into the musculo-cutaneous nerve and into the distal part of the sciatic nerve. Counts of labeled cells showed that the mean percentage of surviving motorneurons was 48.4% in the case of the musculo-cutaneous nerve and 83.6% in the case of the sciatic nerve. The cell loss was not found to be different in old compared to young mutants, suggesting that motorneuron degeneration is an early event in the course of the disease.
利用辣根过氧化物酶的逆行运输技术，将其注入到摇椅突变小鼠的肌皮神经和坐骨神经远端，对支配外周肌肉区域的脊髓运动神经元池进行了研究。标记细胞计数显示，肌皮神经组存活运动神经元的平均百分比为48.4%，坐骨神经组为83.6%。未发现老年突变体与年轻突变体的细胞损失存在差异，这表明运动神经元变性是该疾病病程中的早期事件。
