Totskiĭ V N
Biokhimiia. 1976 Jul;41(6):1094-105.
Experimental evidence of the penetration of low doses (100--120 mkM) of lipoic acid (LA) into cells and mitochondria by means of transport systems, involving proteins was obtained. The functioning of those systems is regulated by hormones, is dependent of redox states, is disturbed in the presence of energy metabolism inhibitors and is stimulated by repeated injections of LA. The penetration of LA into erythrocytes is facilitated by a concentration gradient K+ and Na+ and the high activity of transport ATPases. In case of high (over 120 mkM) content of lipoate in the incubation medium, its penetration into the cells and mitochondria occurs largely due to ordinary diffusion. Such penetration of LA predominantly occurs also under conditions of transversely directed gravitational overloading (6g). The rate of LA penetration into the biological structures of the organism is regulated by complicated and efficient mechanisms, involving hormonal control of protein biosynthesis.
获得了低剂量（100 - 120微摩尔）硫辛酸（LA）借助涉及蛋白质的转运系统进入细胞和线粒体的实验证据。这些系统的功能受激素调节，依赖于氧化还原状态，在能量代谢抑制剂存在时受到干扰，并通过重复注射LA而被刺激。K⁺和Na⁺的浓度梯度以及转运ATP酶的高活性促进了LA进入红细胞。在孵育培养基中硫辛酸含量高（超过120微摩尔）的情况下，其进入细胞和线粒体主要是由于普通扩散。LA的这种渗透在横向定向重力过载（6g）条件下也主要发生。LA进入生物体生物结构的速率受复杂而有效的机制调节，包括对蛋白质生物合成的激素控制。
