雅典饮用水有机提取物的致突变和致染色体断裂效应。

Mutagenic and clastogenic effects of organic extracts from the Athenian drinking water.

作者信息

Athanasiou K, Kyrtopoulos S A

出版信息

Sci Total Environ. 1983 Apr;27(2-3):113-20. doi: 10.1016/0048-9697(83)90150-x.

Abstract

Organic extracts of chlorinated drinking water collected from the water distribution system of Athens, Greece, were tested in parallel for their ability to cause mutations in the Salmonella His+ reversion system and sister chromatid exchanges (SCE) and chromosomal aberrations in CHO cells. They were found to induce His+ revertants in frequencies similar to those detected previously with drinking water extracts from other areas around the world. We observe that organic samples from surface drinking water induce SCE and chromatid type abnormalities in CHO cell cultures while samples collected from ground drinking water did not. These findings confirm that chlorinated surface drinking water contains substances which are mutagenic and clastogenic and may be carcinogenic in humans.

摘要

从希腊雅典供水系统采集的氯化饮用水有机提取物，同时进行了测试，以检测其在沙门氏菌组氨酸回复突变系统中诱发突变的能力，以及在CHO细胞中诱发姐妹染色单体交换（SCE）和染色体畸变的能力。结果发现，它们诱导组氨酸回复突变体的频率与之前在世界其他地区饮用水提取物中检测到的频率相似。我们观察到，来自地表饮用水的有机样品在CHO细胞培养物中诱发SCE和染色单体类型异常，而从地下饮用水采集的样品则未诱发。这些发现证实，氯化地表饮用水含有具有致突变性、断裂性且可能对人类致癌的物质。