慢性自主神经功能衰竭患者的黏液纤毛清除功能
Mucociliary clearance in patients with chronic autonomic failure.
作者信息
Jenkins P, Pavia D, Bateman J R, Clarke S W, Citron K M, Bannister R
出版信息
Thorax. 1980 Sep;35(9):690-3. doi: 10.1136/thx.35.9.690.
Mucociliary clearance was measured in four patients with chronic autonomic failure and normal ventilatory function using a method of scanning the clearance of inhaled polystyrene particles tagged with 99mTc. Previous surgical and experimental evidence has suggested that autonomic denervation might be expected to impair clearance. However, the four patients in this study showed no significant difference in clearance rate compared to groups of sex-matched control subjects. A fifth patient was found to have impaired mucociliary clearance. However she had the symptoms and ventilatory function of smoking-related chronic obstructive bronchitis, a condition which has previously been shown to impair mucociliary clearance.
采用扫描标记有99mTc的吸入聚苯乙烯颗粒清除率的方法，对4例慢性自主神经功能衰竭且通气功能正常的患者进行了黏液纤毛清除功能检测。既往手术及实验证据表明，自主神经去神经支配可能会损害清除功能。然而，本研究中的4例患者与性别匹配的对照组相比，清除率无显著差异。发现第5例患者的黏液纤毛清除功能受损。然而，她有与吸烟相关的慢性阻塞性支气管炎的症状和通气功能，此前已证明这种疾病会损害黏液纤毛清除功能。
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