Arnold G, Holtzman E
Brain Res. 1978 Oct 20;155(1):1-17. doi: 10.1016/0006-8993(78)90300-1.
The distribution of catalase-containing microperoxisomes was studied in the central nervous system of rats during the early postnatal period when the processes of myelination and cell differentiation are active. The regions selected for study included a region previously found in adult animals to contain substantial numbers of reactive microperoxisomes, as well as areas where few such bodies were seen. Microperoxisomes were relatively numerous in all areas during the first two postnatal weeks; at later times they occurred less frequently, or, in some areas, were almost entirely absent. In early postnatal CNS, catalase-positive microperoxisomes were found in all cell types in all regions studied. Neurons of both cerebrum and cerebellum contained catalase-positive microperoxisomes during the first two postnatal weeks; few such neuronal bodies are found in these areas after the third postnatal week. During the period of active myelination, catalase-positive microperoxisomes were found in oligodendrocyte cell bodies, and also in oligodendrocyte processes associated with forming myelin sheaths in all areas. In several areas during the first 3 postnatal weeks, catalase-positive bodies were seen in synaptic terminals, a location where they are seldom observed in mature tissue. Cells of postnatal choroid plexus also were found to contain modest numbers of reactive microperoxisomes.
在出生后早期，当髓鞘形成和细胞分化过程活跃时，对大鼠中枢神经系统中含过氧化氢酶的微过氧化物酶体的分布进行了研究。选择进行研究的区域包括先前在成年动物中发现含有大量反应性微过氧化物酶体的区域，以及几乎看不到此类小体的区域。在出生后的前两周，所有区域的微过氧化物酶体相对较多；在后期，它们出现的频率较低，或者在某些区域几乎完全不存在。在出生后早期的中枢神经系统中，在所研究的所有区域的所有细胞类型中都发现了过氧化氢酶阳性微过氧化物酶体。在出生后的前两周，大脑和小脑的神经元都含有过氧化氢酶阳性微过氧化物酶体；在出生后第三周后，在这些区域很少发现此类神经元小体。在活跃的髓鞘形成期，在少突胶质细胞胞体中以及在所有区域与形成髓鞘相关的少突胶质细胞突起中都发现了过氧化氢酶阳性微过氧化物酶体。在出生后的前三周，在几个区域的突触终末中可见过氧化氢酶阳性小体，在成熟组织中很少在这个位置观察到它们。还发现出生后脉络丛的细胞含有适量的反应性微过氧化物酶体。
