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大鼠中枢神经系统中的微过氧化物酶体分布

Microperoxisome distribution in the central nervous system of the rat.

作者信息

McKenna O, Arnold G, Holtzman E

出版信息

Brain Res. 1976 Nov 26;117(2):181-94. doi: 10.1016/0006-8993(76)90729-0.

DOI:10.1016/0006-8993(76)90729-0
PMID:990913
Abstract

The distribution of microperoxisomes was studied in areas of the central nervous system having high concentrations of catecholaminergic neurons and in areas lacking this neuron type, using the alkaline DAB cytochemical method for catalase. Substantial numbers of microperoxisomes are found in neurons in the locus coeruleus and in nucleus A1 of the medulla, as well as in the substantia nigra, whereas few catalase-reactive bodies are seen in neurons of the cerebrum and cerebellum. The number of catalase-reactive microperoxisomes per unit area in the catecholaminergic neurons of the CNS is comparable to the number seen previously in neurons of the peripheral cervical sympathetic ganglia. Some spinal cord neurons also contain reactive microperoxisomes. Catalase-reactive microperoxisomes are numerous in oligodendrocytes of all areas studied, and in ependymal cells bordering the third and fourth ventricles. Astrocytes contain few reactive structures in the cytoplasm near the nucleus, but they are readily found in astrocytic processes and end-feet.

摘要

采用碱性二氨基联苯胺(DAB)过氧化氢酶细胞化学方法,研究了中枢神经系统中儿茶酚胺能神经元浓度高的区域以及缺乏这类神经元的区域中微小过氧化物酶体的分布情况。在蓝斑核、延髓A1核以及黑质的神经元中发现了大量微小过氧化物酶体,而在大脑和小脑的神经元中则很少见到过氧化氢酶反应阳性小体。中枢神经系统中儿茶酚胺能神经元每单位面积的过氧化氢酶反应阳性微小过氧化物酶体数量与先前在颈交感神经节外周神经元中所见数量相当。一些脊髓神经元也含有反应性微小过氧化物酶体。在所研究的所有区域的少突胶质细胞以及第三和第四脑室周围的室管膜细胞中,过氧化氢酶反应阳性微小过氧化物酶体数量众多。星形胶质细胞在靠近细胞核的细胞质中含有少量反应性结构,但在星形胶质细胞的突起和终足中很容易发现它们。

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