Effect of C31G, an antimicrobial surfactant, on healing of incised guinea pig wounds.

An anti-infective surfactant composition (C31G) promoted healing of infected and noninfected wounds in guinea pigs. In this animal model, histologic features of wounds treated topically with C31G revealed an increased rate of wound closure associated with decreased inflammatory response and increased C31G fibroblast infiltration and epithelialization. The effect of C31G on fibrin formation, the initial event of wound healing, was compared with effects of anionic and cationic surfactants that delay healing. The surfactants had different effects on clotting time, platelet activation, and cross-linkage of the stabilized clot. Seemingly, C31G increased the protein cross-linking of fibrin in clots containing fibronectin.