Young R C, Canellos G P, Chabner B A, Hubbard S M, DeVita V T
Cancer. 1978 Aug;42(2 Suppl):1001-7. doi: 10.1002/1097-0142(197808)42:2+<1001::aid-cncr2820420723>3.0.co;2-z.
One hundred sixty-one patients with advanced Hodgkin's disease achieved complete remission after combination chemotherapy. Of these, 52 (32%) have subsequently relapsed and the patterns of relapse have been studied. The probability of relapse increases with increasing stage and particularly with the presence of systemic symptoms. Patients with Nodular Sclerosis histology are more likely to relapse than those with other histologies. Patients relapse primarily (92%) in sites of previous disease and particularly in nodal sites (75%). Nodal sites most frequently involved at relapse are the central nodal areas and the left supraclavicular area. When patients relapse in new sites they tend to be either adjacent to sites of previous disease which relapse or to be contiguous with previously involved sites of disease. In the small number of patients who received prophylactic radiation therapy to sites of nodal disease after complete remission, the pattern of relapse was not significantly altered.
161例晚期霍奇金病患者在联合化疗后实现完全缓解。其中，52例（32%）随后复发，且对复发模式进行了研究。复发概率随分期增加而升高，特别是存在全身症状时。结节硬化组织学类型的患者比其他组织学类型的患者更易复发。患者主要（92%）在既往病变部位复发，尤其是淋巴结部位（75%）。复发时最常累及的淋巴结部位是中央淋巴结区和左锁骨上区。当患者在新部位复发时，往往与既往复发的病变部位相邻或与既往受累的病变部位相连。在少数完全缓解后接受了淋巴结疾病部位预防性放射治疗的患者中，复发模式未发生显著改变。
