Funakoshi A, Wakasugi H, Kimura T, Matsumoto M, Ibayashi H
Gastroenterol Jpn. 1978;13(5):390-4. doi: 10.1007/BF02776016.
Serum Ribonuclease (RNase, EC. 3. 1. 4. 22) of normal persons and of patients with chronic pancreatitis, or pancreatic cancer was determined with poly (C) as substrate. Strikingly abnormal elevations occured in the serum RNase of patients with pancreatic cancer (p less than 0.001). Average serum RNase values of 18 normal persons, 10 patients with chronic pancreatitis and 26 patients with pancreatic cancer were 92, 118, and 249 units, respectively. In patients with pancreatic cancer, we compared the RNase level with four histologic types (ductar cell adenocarcinoma, anaplastic cell carcinoma, acinar cell carcinoma, and islet cell carcinoma). Adenocarcinoma showed higher activity than the other histologic types (p less than 0.005). When we compared the serum of pancreatic cancer and pancreatic cancer tumor extract with normal serum and normal pancreas extract, strikingly different phosphocellulose chromatographic pattern were evident. The correlation of increased serum RNase levels with tumor histology and different chromatographic pattern may explain the new enzyme production in cancer patients, and have biological significance in the development of pancreatic cancer.
以聚（C）为底物，测定了正常人和慢性胰腺炎或胰腺癌患者的血清核糖核酸酶（RNase，EC. 3. 1. 4. 22）。胰腺癌患者血清RNase显著异常升高（p＜0.001）。18名正常人、10名慢性胰腺炎患者和26名胰腺癌患者的血清RNase平均水平分别为92、118和249单位。在胰腺癌患者中，我们将RNase水平与四种组织学类型（导管细胞腺癌、间变性细胞癌、腺泡细胞癌和胰岛细胞癌）进行了比较。腺癌的活性高于其他组织学类型（p＜0.005）。当我们将胰腺癌血清和胰腺癌肿瘤提取物与正常血清和正常胰腺提取物进行比较时，明显呈现出截然不同的磷酸纤维素色谱图谱。血清RNase水平升高与肿瘤组织学及不同色谱图谱之间的相关性，可能解释了癌症患者新酶的产生，并在胰腺癌的发生发展中具有生物学意义。
