Del Favero G, Basso D, Fabris C, Angonese C, Meani A, Vianello D, Pedrazzoli S, Dodi G, Naccarato R
Istituto di Medicina Interna, Cattedra di Malattie dell'Apparato Digerente, Università degli Studi di Padova, Italy.
Int J Pancreatol. 1988;3 Suppl 1:S107-12.
In this study we evaluated some pathophysiological aspects of pancreatic and liver ribonucleases and alkaline deoxyribonuclease and their clinical usefulness in diagnosing pancreatic cancer. Pancreatic RNase was found to be a sensitive index of pancreatic malignancy; however it was not specific in distinguishing pancreatic malignancy from chronic pancreatitis or other pathologies. Liver RNase and alkaline DNase did not provide better results than pancreatic RNase. These three enzymes were found to be age-dependent and related to each other. Therefore serum nucleases are not useful for clinical purposes since they are influenced, at least in part, by different non-specific factors.
在本研究中，我们评估了胰腺和肝脏核糖核酸酶及碱性脱氧核糖核酸酶的一些病理生理学方面，以及它们在诊断胰腺癌中的临床应用价值。发现胰腺核糖核酸酶是胰腺恶性肿瘤的一个敏感指标；然而，在区分胰腺恶性肿瘤与慢性胰腺炎或其他病症方面它并不具有特异性。肝脏核糖核酸酶和碱性脱氧核糖核酸酶的诊断效果并不比胰腺核糖核酸酶更好。发现这三种酶与年龄相关且相互关联。因此，血清核酸酶对临床诊断并无用处，因为它们至少部分受到不同非特异性因素的影响。
