Reddi K K, Holland J F
Proc Natl Acad Sci U S A. 1976 Jul;73(7):2308-10. doi: 10.1073/pnas.73.7.2308.
Serum RNase (ribonuclease) of normal persons and of patients with pancreatitis, carcinoma of pancreas, or other neoplasms was determined with poly(C) as substrate. Strikingly abnormal elevations occur in the serum RNase of patients with pancreatic cancer. There is no elevation in the serum RNase level of patients with pancreatitis. Average serum RNase values of 52 normal persons, 10 patients with pancreatitis, 30 patients with pancreatic cancer, 28 patients with breast cancer, 11 patients with lung cancer, 20 patients with colon cancer, six patients with stomach cancer, and four patients with liver cancer, respectively, were 104, 120, 383, 131, 173, 197, 194, and 152 units/ml of serum. Ninety percent of the patients with pancreatic cancer were above the level of 250 units of serum and 90% of all patients with varied cancers were below this level. In the presence of severe renal insufficiency, marked elevation of serum RNase was also observed. Serum RNase, because of its unique specificity, pancreatic origin, and its abnormal elevation in sera of patients with pancreatic cancer, serves as a reliable biochemical marker of carcinoma of the pancreas in the presence of normal renal function.
以聚（C）为底物测定了正常人和胰腺炎、胰腺癌或其他肿瘤患者的血清核糖核酸酶（RNase）。胰腺癌患者的血清RNase显著异常升高。胰腺炎患者的血清RNase水平没有升高。52名正常人、10名胰腺炎患者、30名胰腺癌患者、28名乳腺癌患者、11名肺癌患者、20名结肠癌患者、6名胃癌患者和4名肝癌患者的血清RNase平均水平分别为104、120、383、131、173、197、194和152单位/毫升血清。90%的胰腺癌患者血清水平高于250单位，而所有不同癌症患者的90%低于该水平。在严重肾功能不全的情况下，也观察到血清RNase显著升高。血清RNase因其独特的特异性、胰腺来源以及在胰腺癌患者血清中的异常升高，在肾功能正常的情况下可作为胰腺癌可靠的生化标志物。
